cees dekker - An Overview
cees dekker - An Overview
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Nanotechnology presents An array of opportunities to contribute to biology. Right here I will current illustrations where nanofabrication – the ability to make confined structures with dimensions at will – is utilized to examine the biophysics of single molecules and cells. I will present some examples from our lab:
Our team reports bacterial cell division and it is aiming to represent a ‘base up biology’ in synthetic cells that can autonomously divide. Our main interest lies in mobile division, chromatin construction, and spatial Manage.
As a human being, I hold the biblical assignment to take a look at and use every thing in development for the advantage of my neighbour. I don't knowledge any conflict concerning religion and science. On the contrary, my faith stimulates me to accomplish science, to get open up-minded in the world.’
Regretably, For a long time after Iijima’s report, the manufacture of clean up nanotubes was cumbersome. In 1996, even so, the team of Richard Smalley at Rice University managed to create one-walled carbon nanotubes at large generate. Shortly right after, I contacted Smalley, and we made a decision to join forces to measure the transportation by way of a one carbon nanotube.
2015, discovery that condensin is actually a highly adaptable protein construction; and first detection of DNA knots applying nanopores
Case in point (3) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim of your pore is highlighted in pink, plus a 3D rendering from the movement on the DNA rod is displayed.
We shape microbes into varieties that deviate from their pure phenotype. Precisely, I'll present our capability to shape Are living E. coli micro organism into novel designs like rectangles, squares, triangles and circles.
Stream-pushed rotary motors which include windmills and drinking water wheels push useful procedures in human Modern society. Whilst samples of such rotary motors also function prominently in cell biology, their synthetic building on the nanoscale has remained demanding. Below we display move-pushed rotary movement of the self-arranged DNA nanostructure that is definitely docked on to a nanopore in a thin reliable-condition membrane. An elastic DNA bundle self-assembles into a chiral conformation upon phoretic docking onto the reliable-condition nanopore, and subsequently displays a sustained unidirectional rotary motion of up to 20 rev s−one.
‘You should not just take into consideration the queries of tomorrow, but additionally think about the concerns from the day after tomorrow’
Quite neat, but that wasn’t actually wherever my interest lay. I desired to pioneer And that i experienced the sensation that was not doable, because the most intriguing elementary insights experienced presently been uncovered. But my subject experienced created several enjoyable new tools to measure personal molecules. I made a decision which i needed to apply this to biology, to look at it from a Bodily viewpoint.’
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
Afterwards we spoke once more briefly due to the fact Dekker felt that our dialogue of his religion immediately turned purely philosophical, whereas In addition, it concretely will help him in his get the job done.
Permit’s to start with glimpse again in the mean time if you chose to change your https://www.ceesdekker.net emphasis from superconductivity and nanotubes to biology at the conclusion of the nineties.
Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and one-molecule experiments